Generally, my lab focuses on two topics: 1) cryo-electron tomography (cryo-ET), and 2) its application in in-situ structural biology, especially in emerging enveloped viruses.
We have written two articles for popular science presses to present the general ideas of both topics: the cryo-ET was introduced on “Fanpu (返朴)”, and the enveloped viruses on “Zhishifenzi (知识分子)”.
Workflow on solving the LASV spike structure
Details in Li et al. Plos Pathogens (2016), Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike
Mapping the epitopes on the hantaviral surface
Details in Li et al. Cell Reports (2016), A Molecular-Level Account of the Antigenic Hantaviral Surface